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Dr Alexander Lehner
 Post held
Senior Lecturer in Human Nutrition
Contact Details
Office: Brampton 20
Telephone: +44 (0) 1604 89 2669
Email: alex.lehner@northampton.ac.uk
Qualifications
Module Leader
Undergraduate
HLS1003 - Molecular Biology of the Cell
HLS1016 - Introduction to Human Nutrition
HLS2006 - Nutritional Perspective of Health and Disease
HLS2007 - Processes of Life: Biochemistry
HLS3005 - Communities and Nutrition
Postgraduate
HLSM102 - Nutrition in a Global Context
Other Modules Contributed to:
HLS1006 - Concepts of Health
HLS1007 - Health over the Lifespan
HLS1012 - Integrated Physiology
HLS2012 - Health in Later Life
HLS2013 - Body Matters
HLS2016 - Research Methods
HLS3007 - Health Risk and Environment
HLS3009 - Immunology
HLS3011 - Researching Populations Health
HLS3013 - Ethical Issues in Health
HLS3014 - Integrated perspectives in Health and Disease
HLS3016 - Sport and Exercise Nutrition
HLS4001 - Human Biology Dissertation
HLS4005 - Health Studies Dissertation
NPR1002 - Life Sciences for Healthcare Professionals
HLSM100 - Bioethics
Supervisor to PhD Candidate in the School of Health
Kennedy Mdaki:
Characterisation of uncoupling via inactivation of mitochondrial aconitase
Supervisor to PhD Candidate in the School of Science and Technology
Yonggang Duan (Completed 2008):
Novel crosslinked collagen matrix: assessment for efficacy as wound dressing
Research Interests
My research interests revolve around biological energy balance in relation to lifestyle environments, ageing, and chronic disease.
My laboratory research attempts to answer questions at the level of the mitochondrion with regard to energy efficiency and the regulation and dysregulation of oxidative stress. A key question behind my studies is how dietary components, both nutrients and contaminants, especially metals, affect mitochondrial function to result in homeostasis or disease. We are currently elucidating a new model of energy regulation and exploring how it ties together specifically the chronic diseases: Obesity, Diabetes Mellitus, Cardiovascular disease, cancer and Alzheimer's disease. The hypothesis underlying the model is that The central nervous system is used by the mitochondria to coordinate all energy related processes in the human body.
I have in the past also worked on a large clinical trial to determine the effect of Vitamin E on exercise induced oxidative stress in relation to CVD, explored the effects of oxidation on specific enzymes, and have investigated how certain proteins regulate mRNA export from the nucleus.
Outside of the laboratory we have recently completed a study which evaluated the effectiveness of government funded school based interventions on children's eating behaviour, including drama based interventions. The study included investigating dietary intakes and assessing body composition, as well as the children's dietary understanding. As a Result of this study and my association with Benevolent Ballet, we are now pursuing further interdisciplinary research to elucidate a new model of empathic engagement. This model connects the principles of behaviour modification with the principles of cellular and organismal energy metabolism to develop a unified and applicable theory of bioenergetics.
Publications
Journal Articles
- Apponi LH, Kelly SM, Harreman MT, Lehner AN, Corbett AH, Valentini SR. (2007)
An Interaction between Two RNA Binding Proteins, Nab2 and Pub1, Links mRNA Processing/Export and mRNA Stability. Mol Cell Biol. Sep;27(18):6569-79. Epub 2007 Jul 16
- Karabina SA*, & Lehner AN*, Frank E, Parthasarathy S, Santanam N. (2005) Oxidative inactivation of paraoxonase--implications in diabetes mellitus and atherosclerosis. Biochim Biophys Acta, Sept 15;1725(2):213-21 . *Both authors contributed equally to this work
Lehner, A.N. and Parthasarathy, S. Inactivation of Aconitase by Lysine modification (in preparation)
Harreman, M. T., Green D. M., Lehner, A. N., Fasken, M. B., Leung, S., Ordanic-Kodani, M., Marfatia, K. A., and Corbett, A. H., The C-termini of Mlp1 and Mlp2 interact with the N-terminus of the hnRNP Nab2p to regulate mRNA export from the nucleus. (in preparation)
Abstracts
- Parthasarathy S, Karabina SA, Lehner AN, Frank E, Santanam N, (2004) Mechanism of action of Paraoxonase, Arteriosclerosis, Thrombosis, and Vascular Biology, May 24(5): e104;P308
- Earle D, Lehner A, Santanam N, White-Welkley J, Parthasarathy, S (2002) Autoantibodies to oxidized Low-Density Lipoprotein in Sedentary women after 8 weeks of exercise of Exercise, Medicine and Science in Sport and Exercise, May 34(5): s80
Presentations
- Alexander N Lehner (2009) Empathic Engagement: A New Model. Inspiring Transformations: Applied Arts and Health, Northampton, UK
- E. Rubinson, S. Leung, S. Kerr, M.T. Harreman, A. Lehner, A.H. Corbett, and M. Ordanic-Kodani (2005). The Yeast hnRNP Interacts with the RING Finger Protein, Air1p. Southeast Regional Yeast Meeting, Atlanta, GA USA
- Drex Earle, Alex Lehner, Jill Welkley, Nalini Santanam, Sampath Parthasarathy (2002) Autoantibodies to Oxidized Low-Density Lipoprotein in Sedentary Women after 8 Weeks of Exercise, American College of Sports Medicine Conference Thematic Presentation, St. Louis, MO USA
- Drex Earle, Alex Lehner, Jill Welkley, Nalini Santanam, Sampath Parthasarathy (2002) Exercise & CVD, Nutrition Health Sciences Poster Session, Atlanta ,GA USA
- Drex Earle, Alex Lehner, Jill Welkley, Nalini Santanam, Sampath Parthasarathy (2001) Exercise & CVD: A new perspective, Oxidation & Signaling in Chronic Diseases Symposium Poster Presentation, Rutherford, GA USA
- Alex Lehner, Sampath Parthasarathy (2001), Diabetes and Hypertriglyceridemia: A novel Hypothesis, Oxidation & Signaling in Chronic Diseases Symposium Rutherford, GA USA
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