Dr Stuart M Raleigh

Stuart RaleighPost Held

Senior Lecturer in Human Biology

Contact Details

Office: Brampton 19
Telephone: (01604) 892306
Email: Stuart.Raleigh@northampton.ac.uk

Qualifications

  • PG cert in Research Degree Supervision, University of Northampton (2005)
  • PGCE in Biology, University of Leicester (2000)
  • PhD: Molecular Pharmacology, De Montfort University (1998)
  • BSc (Honours) Biochemistry, University of York (1991)

Research interests

My main areas of interests are focused on population genetics and gene variants that may predispose to certain types of human pathology.Specifically, I am engaged in the following fields of research:

  • Molecular genetics of soft tissue pathology and predisposition to injury
  • Molecular genetics of cardio-respiratory function
  • Exercise biochemistry

Teaching interests

  • HLS2001: Genes and Genomics
  • HLS2004: Health and Disease
  • HLS1002: Cellular Communication
  • HLS1003: Molecular Biology of the Cell
  • HLS3008: Heredity and Society
  • HLS2016: Researching Life Science
  • HLS3007: Health, risk and Society
  • HLS3009: Immunology
  • HLS4001/2/3: Bioscience research dissertations

Membership

  • European Society for Human Genetics
  • Biochemical Society
  • General Teaching Council

Editorial Reviewer for:

  • Journal of Applied Physiology
  • British Journal of Sports Medicine
  • National Research Foundation of South Africa

Recent publications

  • Raleigh, S.M., Van Der Merwe, L., Ribbans, W.J., Smith, R.K., Shwellnus, M. P., Collins, M (2008). Variants within the MMP3 gene are associated with Achilles Tendinopathy: Possible interaction with the COL5A1 gene.  British Journal of Sports Medicine (in press)
  • Tobin, M.D., Maciej, T., Braund, P., Hajat, C., Raleigh, S.M., Palmer, T.H., Caulfield M., Burton, P.R., Samani,N.J. (2008)  Common variation in genes underlying monogenic forms of hypertension and hypotension and ambulatory blood pressure in the general population.. Hypertension, 51, 1658-1664
  • Raleigh, S.M., Davies, B., Cleal, D., Ribbans, W (2007).  No association between coding polymorphism within exon 4 of the human surfactant protein b gene and pulmonary function in healthy men.  The Journal of Physiological Sciences, 57, 199-202.
  • The British Heart Foundation (BHF) Family Heart Study Group (S. Raleigh a member of the BHF Family Heart Study Group), (2005).  A genomewide linkage study of 1,933 families affected by premature coronary artery disease.  American Journal of Human Genetics, 77, 1011-1020
  • Tobin, M.D., Raleigh, S.M., Newhouse, S., Braund, P., Bodycote, C., Ogleby, J., Cross, D., Gracey, J., Hayes, S., Smith T., Ridge,C., Caulfield M., Sheehan N.A., Munroe P.B., Burton P.B., Samani N.J. (2005).  Association of PRKWNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.  Circulation, 112, 3423-3429
  • Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J., Braund, P., Clemitson, J R., Mason, A., Bodycote, C., Raleigh, S. M., Louis, E., and Samani, N J., (2005), Mapping of a major locus determining telomere length in humans American Journal of Human Genetics. 76:147-151
  • Raleigh, S. M., Verschoyle, R. D., Bowskill, C., Pastorino, U., Staniforth, J. N., Steele, F., Dinsdale, D., Carthew, P., Lim, C. K., Silvester, J. and Gescher, A., (2000), Pulmonary availability of isotretinoin (13-cis-retinoic acid) after aerosol inhalation.  British Journal of Cancer, 83, 935-940.
  • Patterson, L. H., McKeown, S. R., Robson, T., Gallagher, R., Raleigh, S. M. and Orr, S., (1999), Antitumour prodrug development using cytochrome P450 mediated activation.  Anticancer Drug Design, 14, 473-486.
  • Raleigh, S. M., Wanogho, E., Burke, M. D. and Patterson, L. H., (1999), Cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug.  Xenobiotica, 29, 1115-1122.
  • Raleigh, S. M., Wanogho, E., Burke, M. D., McKeown, S. R. and Patterson, L. H., (1998), Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug.  International Journal of Radiation Oncology Biology Physics, 42, 763-767.
  • Patterson, L. H. and Raleigh, S. M., (1998), Reductive metabolism: Its application to prodrug activation.  In N. J. Gooderham (ed.), Drug metabolism: Towards the next Millennium (Amsterdam: IOS Press), pp72-79.
  • Padgham, C. R., Boyle, C.C., Wang, X. J., Raleigh, S. M., Wright, M., C. and Paine, A. J., (1993), Alteration of transcription factor mRNA during the isolation and culture of hepatocytes suggests the activation of a proliferative mode underlies their de-differatiation.  Biochemical and Biophysical Research Communications, 197, 599-603.

International patent applications

  • Provisional patent (joint application with the University of Cape Town and The South African Medical Research Council). patent no. 2008/09435.

International conference presentations (2005-present)

  • Collins, M., Raleigh, SM., Van der Merwe, L., Ribbans, W.J., Smith, R.K.W., Shwellnus, M., Collins, M. variants within the MMP3 gene are associated with Achilles tendinopathy: Submitted to the South African Society for Human Genetics Coference, Spier, Stellenbosch for presentation April, 2009
  • Raleigh, SM., Van der Merwe, L., Ribbans, W.J., Smith, R.K.W., Shwellnus, M., Collins, M. variants within the MMP3 gene are associated with Achilles tendinopathy: Presented at the FIMS Congress of Sports Medicine, Barcelona, Spain, November, 2008
  • Tomaszewski, M., Tobin MD, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ.  Common variants in the gene underlying type 2 Bartter syndrome are associated with blood pressure in the general population - The results of the genetic scan in the GRAPHIC (genetic regulation of arterial pressure of humans in the community) study. Journal of Hypertension, 26: S12-S12, Suppl. 1 (2008)
  • Collins, M and Raleigh , SM. The Genetics of Soft Tissue Injury (Invited book chapter) in the series 'Medicine and Sports Science' Karger press
  • Braund, P., Tobin, M., Lavery, G., Bodycote, C., Raleigh, S. M., Charchar, F., Burton, P., and Samani, N., (2006), Angiotensinogen gene variants do not affect ambulatory blood pressure in the general population.  Poster presentation Hypertension, 48, 4, E64.
  • Tobin, M. D., Sheehan, N. A., Raleigh, S. M., Samani, N. J., Burton, P. R., (2004) Characterising Phenotype in Genetic Studies of Blood Pressure.  Abstract 128.  Orally presented at the American Society of Human Genetics Annual Meeting
 

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